Recombinant人SOD2/MnSOD protein (ab82656)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      25 to 222

技术指标

Our Abpromise guarantee covers the use of ab82656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20mM HEPES, pH 7

  • 复溶
    Reconstitute in 500µl of DW

常规信息

  • 别名
    • Indophenoloxidase B
    • IPO B
    • IPOB
    • Manganese containing superoxide dismutase
    • Manganese SOD
    • Manganese superoxide dismutase
    • Mangano superoxide dismutase
    • Mn SOD
    • Mn superoxide dismutase
    • MNSOD
    • MVCD6
    • SOD 2
    • SOD2
    • SODM_HUMAN
    • Superoxide dismutase [Mn] mitochondrial
    • Superoxide dismutase [Mn], mitochondrial
    • Superoxide dismutase 2 mitochondrial
    see all
  • 功能
    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • 疾病相关
    Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • 序列相似性
    Belongs to the iron/manganese superoxide dismutase family.
  • 翻译后修饰
    Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
  • 细胞定位
    Mitochondrion matrix.
  • Information by UniProt

Recombinant Human SOD2/MnSOD protein 图像

  • ab82656 at 1µg on SDS-PAGE.

Recombinant Human SOD2/MnSOD protein (ab82656)参考文献

ab82656 has not yet been referenced specifically in any publications.

Product Wall

This protein is the full length SOD2 protein without the transit peptide which corresponds to amino acids 1-24.

Therefore the protein consists of amino acids 25-222 of the human protein: http://www.uniprot.org/uniprot/P04179

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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