Recombinant人SMAD5 protein (ab84651)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab84651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • DKFZp781C1895
    • DKFZp781O1323
    • Dwfc
    • hSmad5
    • JV5 1
    • JV5-1
    • MAD homolog 5
    • MAD, mothers against decapentaplegic homolog 5
    • MADH 5
    • MADH5
    • Mothers against decapentaplegic homolog 5
    • mothers against decapentaplegic, drosophila, homolog of, 5
    • Mothers against DPP homolog 5
    • MusMLP
    • SMA and MAD related protein 5
    • SMAD 5
    • SMAD family member 5
    • SMAD, mothers against DPP homolog 5
    • Smad5
    • SMAD5_HUMAN
    see all
  • 功能
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the dwarfin/SMAD family.
    Contains 1 MH1 (MAD homology 1) domain.
    Contains 1 MH2 (MAD homology 2) domain.
  • 翻译后修饰
    Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
    Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
  • 细胞定位
    Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
  • Information by UniProt

图片

  • SDS-PAGE showing ab84651 at approximately 82kDa.

文献

ab84651 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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