Recombinant人SLC12A1 protein (ab114560)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      AKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRP SLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQA
    • 分子量
      36 kDa including tags
    • 氨基酸
      80 to 172

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BSC1
    • Bumetanide sensitive sodium 3
    • Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
    • Kidney specific Na K Cl symporter
    • Kidney-specific Na-K-Cl symporter
    • MGC48843
    • Na K 2Cl cotransporter
    • NKCC2
    • potassiumchloride cotransporter 2
    • S12A1_HUMAN
    • Slc12a1
    • sodium potassium chloride cotransporter 2
    • solute carrier family 12 (sodium/potassium/chloride transporters)
    • Solute carrier family 12 member 1
    see all
  • 功能
    Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
  • 组织特异性
    Kidney specific.
  • 疾病相关
    Defects in SLC12A1 are the cause of Bartter syndrome type 1 (BS1) [MIM:601678]. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS1 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS1 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 序列相似性
    Belongs to the SLC12A transporter family.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE Stained with Coomassie Blue

文献

ab114560 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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