Recombinant人SKP2 protein (ab114386)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ13309
    • 种属Human
    • 序列EHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNT LAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQ VAVAHVSETI
    • 分子量38 kDa including tags
    • 氨基酸176 to 285

技术指标

Our Abpromise guarantee covers the use of ab114386 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    ab114386 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • CDK2/Cyclin A associated protein p45
    • Cyclin A/CDK2 associated protein p45
    • Cyclin-A/CDK2-associated protein p45
    • F box protein Skp2
    • F box/LRR repeat protein 1
    • F-box protein Skp2
    • F-box/LRR-repeat protein 1
    • FBL 1
    • FBL1
    • FBXL 1
    • FBXL1
    • FLB 1
    • FLB1
    • MGC1366
    • p45
    • p45skp2
    • S phase kinase associated protein 2
    • S phase kinase associated protein 2 (p45)
    • S-phase kinase-associated protein 2
    • S-phase kinase-associated protein 2 E3 ubiquitin protein ligase
    • SKP 2
    • Skp2
    • SKP2_HUMAN
    see all
  • 功能Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 F-box domain.
    Contains 9 LRR (leucine-rich) repeats.
  • Information by UniProt

Recombinant Human SKP2 protein 图像

  • ab114386 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human SKP2 protein (ab114386)参考文献

ab114386 has not yet been referenced specifically in any publications.

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