Recombinant人SIT protein (ab113580)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9Y3P8
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMHLSQWTRGRSRSHPGQGRSGESVEEVPLY GNLHYLQTGRLSQDPEPDQQDPTLGGPARAAEEVMCYTSLQLRPPQGRIP GPGTPVKYSEVVLDSEPKSQASGPEPELYASVCAQTRRARASFPDQAYAN SQPAAS
    • 分子量17 kDa including tags
    • 氨基酸62 to 196
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab113580 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • gp30/40
    • SHP intracting transmembrane adapter protein
    • SHP2-interacting transmembrane adapter protein
    • Signaling threshold-regulating transmembrane adapter 1
    • SIT
    • Sit1
    • SIT1_HUMAN
    • Suppression inducing transmembrane adapter 1
    • Suppression-inducing transmembrane adapter 1
    see all
  • 功能Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
  • 组织特异性Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.
  • 翻译后修饰Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.
  • 细胞定位Cell membrane.
  • Information by UniProt

Recombinant Human SIT protein 图像

  • 15% SDS-PAGE showing ab113580 (3µg).

    Note: Molecular weight on SDS-PAGE will appear higher.

Recombinant Human SIT protein (ab113580)参考文献

ab113580 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"