Recombinant人SIRT2 protein (ab79948)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸50 to 356

技术指标

Our Abpromise guarantee covers the use of ab79948 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 1.4 U/µg. One U =1 pmol/min.
  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • FLJ35621
    • FLJ37491
    • NAD dependent deacetylase sirtuin 2
    • NAD-dependent deacetylase sirtuin-2
    • NAD-dependent protein deacetylase sirtuin-2
    • Regulatory protein SIR2 homolog 2
    • Silencing information regulator 2 like
    • Silent information regulator 2
    • SIR2
    • SIR2 like protein 2
    • Sir2 related protein type 2
    • SIR2, S. cerevisiae, homolog-loke 2
    • SIR2-like protein 2
    • SIR2L
    • SIR2L2
    • SIRT2
    • SIRT2_HUMAN
    • Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae)
    • Sirtuin 2
    • Sirtuin type 2
    see all
  • 功能NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
  • 组织特异性Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
  • 序列相似性Belongs to the sirtuin family.
    Contains 1 deacetylase sirtuin-type domain.
  • 发展阶段Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
  • 翻译后修饰Phosphorylated at the G2/M transition of the cell cycle.
  • 细胞定位Cytoplasm > cytoskeleton. Colocalizes with microtubules.
  • Information by UniProt

Recombinant human SIRT2 protein 图像

  • 12% SDS-PAGE, Coomassie staining.
    Lane 1: ab79948 1µg.
    Lane 2: ab79948 2µg.
    Lane 3: Protein marker.
  • Image showing specific activity of ab79948.

Recombinant human SIRT2 protein (ab79948)参考文献

ab79948 has not yet been referenced specifically in any publications.

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