Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae)
Sirtuin type 2
功能NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
组织特异性Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
序列相似性Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.
发展阶段Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
翻译后修饰Phosphorylated at the G2/M transition of the cell cycle.
细胞定位Cytoplasm > cytoskeleton. Colocalizes with microtubules.