Recombinant人SI protein (ab114715)

概述

  • 产品名称Recombinant人SI protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP14410
    • 种属Human
    • 序列DGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGK GTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINW
    • 分子量37 kDa including tags
    • 氨基酸1728 to 1826

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Isomaltase
    • MGC131621
    • MGC131622
    • Oligosaccharide alpha 1, 6 glucosidase
    • SI
    • sucrase isomaltase
    • sucrase isomaltase alpha glucosidase
    • Sucrase-isomaltase, intestinal
    • SUIS_HUMAN
    see all
  • 功能Plays an important role in the final stage of carbohydrate digestion.
  • 组织特异性Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon.
  • 疾病相关Defects in SI are the cause of congenital sucrase-isomaltase deficiency (CSID) [MIM:222900]; also known as disaccharide intolerance I. CSID is an autosomal recessive intestinal disorder that is clinically characterized by fermentative diarrhea, abdominal pain, and cramps upon ingestion of sugar. The symptoms are the consequence of absent or drastically reduced enzymatic activities of sucrase and isomaltase. The prevalence of CSID is 0.02 % in individuals of European descent and appears to be much higher in Greenland, Alaskan, and Canadian native people. CSID arises due to post-translational perturbations in the intracellular transport, polarized sorting, aberrant processing, and defective function of SI.
  • 序列相似性Belongs to the glycosyl hydrolase 31 family.
    Contains 2 P-type (trefoil) domains.
  • 翻译后修饰The precursor is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen.
    Sulfated.
  • 细胞定位Apical cell membrane. Brush border.
  • Information by UniProt

Recombinant Human SI protein 图像

  • 12.5% SDS-PAGE showing ab114715 at approximately 36.52 kDa stained with Coomassie Blue.

Recombinant Human SI protein (ab114715)参考文献

ab114715 has not yet been referenced specifically in any publications.

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