Recombinant人Shwachman Bodian-Diamond syndrome protein (ab99957)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9Y3A5
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMSIFTPTNQIRLTNVAVVRMKRAGKRFEIA CYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQ TEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTV ILIERAMKDIHYSVKTNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPV NEGKKLKEKLKPLIKVIESEDYGQQLEIVCLIDPGCFREIDELIKKETKG KGSLEVLNLKDVEEGDEKFE
    • 分子量31 kDa including tags
    • 氨基酸1 to 250
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab99957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab99957 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, 2mM DTT, 0.1mM EDTA, pH 8.0

常规信息

  • 别名
    • 4733401P19Rik
    • AI836084
    • CGI 97
    • CGI-97
    • FLJ10917
    • MGC105922
    • Protein 22A3
    • Ribosome maturation protein SBDS
    • sbds
    • SBDS_HUMAN
    • SDS
    • Shwachman Bodian Diamond syndrome protein
    • Shwachman Bodian Diamond syndrome protein homolog
    • Shwachman-Bodian-Diamond syndrome protein
    • SWDS
    see all
  • 功能Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
  • 组织特异性Widely expressed.
  • 疾病相关Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS) [MIM:260400]. SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities.
  • 序列相似性Belongs to the SDO1/SBDS family.
  • 细胞定位Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.
  • Information by UniProt

Recombinant Human Shwachman Bodian-Diamond syndrome protein 图像

  • 15% SDS-PAGE showing ab99957 (3µg).

Recombinant Human Shwachman Bodian-Diamond syndrome protein (ab99957)参考文献

ab99957 has not yet been referenced specifically in any publications.

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