Recombinant人SHP1 protein (ab80217)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab80217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 1 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30oC.
  • 应用

    SDS-PAGE

    Functional Studies

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 70Z-SHP
    • EC 3.1.3.48
    • HCP
    • HCPH
    • Hematopoietic cell phosphatase
    • Hematopoietic cell protein tyrosine phosphatase
    • Hematopoietic cell protein-tyrosine phosphatase
    • HPTP1C
    • Protein tyrosine phosphatase 1C
    • Protein tyrosine phosphatase non receptor type 6
    • Protein tyrosine phosphatase SHP1
    • Protein-tyrosine phosphatase 1C
    • protein-tyrosine phosphatase SHP 1
    • Protein-tyrosine phosphatase SHP-1
    • PTN6_HUMAN
    • PTP 1C
    • PTP-1C
    • PTP1C
    • Ptpn6
    • SH PTP 1
    • SH PTP1
    • SH-PTP1
    • SHP 1
    • SHP 1L
    • SHP1
    • SHP1L
    • tyrosine protein phosphatase non receptor type 6
    • Tyrosine-protein phosphatase non-receptor type 6
    see all
  • 功能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • 组织特异性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Phosphorylated on serine and tyrosine residues.
  • 细胞定位Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt

Recombinant human SHP1 protein (ab80217)参考文献

ab80217 has not yet been referenced specifically in any publications.

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