概述
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产品名称重组人SHP1蛋白
参阅全部 SHP1 蛋白酶 -
蛋白长度Full length protein
描述
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性质Recombinant
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来源Escherichia coli
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氨基酸序列
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种属Human
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标签GST tag N-Terminus
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab61135 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Functional Studies
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形式Liquid
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Preservative: None
Constituents: 50% Sodium chloride, 30% Glycerol, 20mM MOPS, 0.25mM DTT, 0.1mM PMSF, pH 7.5This product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- 70Z-SHP
- EC 3.1.3.48
- HCP
see all -
功能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
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组织特异性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
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序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain. -
翻译后修饰Phosphorylated on serine and tyrosine residues.
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细胞定位Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
- Information by UniProt
图片
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Functional Studies - SHP1 protein (Tagged) (ab61135)Sample Kinase Activity Plot. -
SDS-PAGE - SHP1 protein (Tagged) (ab61135)ab61135 on SDS-PAGE, MW ~93 kDa.
文献
ab61135 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"