Recombinant人SH2D1A/SAP protein (ab101112)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO60880-1
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
    • 分子量16 kDa including tags
    • 氨基酸1 to 128
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab101112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备��贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5

常规信息

  • 别名
    • DSHP
    • Duncan disease SH2 protein
    • Duncan disease SH2-protein
    • EBVS
    • IMD5
    • LYP
    • MTCP1
    • SAP
    • SAP/SH2D1A
    • SH2 domain containing 1A
    • SH2 domain protein 1A
    • SH2 domain-containing protein 1A
    • SH21A_HUMAN
    • SH2D1A
    • Signaling lymphocyte activation molecule associated protein
    • Signaling lymphocytic activation molecule-associated protein
    • SLAM associated protein
    • SLAM associated protein/SH2 domain protein 1A
    • SLAM-associated protein
    • T cell signal transduction molecule SAP
    • T-cell signal transduction molecule SAP
    • XLP
    • XLPD
    see all
  • 功能Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • 组织特异性Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
  • 疾病相关Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • 序列相似性Contains 1 SH2 domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human SH2D1A/SAP protein 图像

  • 15% SDS-PAGE (3 µg)

Recombinant Human SH2D1A/SAP protein (ab101112)参考文献

ab101112 has not yet been referenced specifically in any publications.

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