Recombinant人SFRP4 protein (ab114483)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ6FHJ7
    • 种属Human
    • 序列CNEVTTVVDVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYE WRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSR SN
    • 分子量37 kDa including tags
    • 氨基酸211 to 312

技术指标

Our Abpromise guarantee covers the use of ab114483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Frizzled protein
    • Frizzled protein human endometrium
    • FRP 4
    • FRP4
    • FrpHE
    • human endometrium
    • Secreted frizzled-related protein 4
    • sFRP-4
    • Sfrp4
    • SFRP4_HUMAN
    see all
  • 功能Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
  • 组织特异性Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
  • 序列相似性Belongs to the secreted frizzled-related protein (sFRP) family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 NTR domain.
  • 结构域The FZ domain is involved in binding with Wnt ligands.
  • 细胞定位Secreted. Cytoplasmic in ovarian tumor cells.
  • Information by UniProt

Recombinant Human SFRP4 protein 图像

  • 12.5% SDS-PAGE showing ab114483 at approximately 36.85kDa stained with Coomassie Blue.

Recombinant Human SFRP4 protein (ab114483)参考文献

ab114483 has not yet been referenced specifically in any publications.

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