Recombinant人Serglycin protein (ab116977)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP10124
    • 种属Human
    • 序列MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCL EEKGPMFELLPGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGS GSGSGSGSGSGFLTEMEQDYQLVDESDAFHDNLRSLDRNLPSDSQDLGQH GLEEDFML
    • 分子量43 kDa including tags
    • 氨基酸1 to 158

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技术指标

Our Abpromise guarantee covers the use of ab116977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Chondroitin sulfate proteoglycan core protein
    • Cytolytic granule proteoglycan core protein
    • FLJ12930
    • gp600
    • Hematopoetic proteoglycan core protein
    • Mastocytoma proteoglycan core protein
    • MGC9289
    • OTTHUMP00000019716
    • P.PG
    • PG19 core protein
    • Pgsg
    • Platelet proteoglycan core protein
    • platelet proteoglycan protein core
    • PLATELET PROTEOGLYCAN PROTEIN CORE; PPG
    • PPG
    • PRG
    • PRG1
    • PROTEOGLYCAN 1
    • proteoglycan 1, secretory granule
    • Proteoglycan 10K core protein
    • Proteoglycan peptide core protein
    • PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE
    • secretory granule proteoglycan 1
    • Secretory granule proteoglycan core peptide
    • Secretory granule proteoglycan core protein
    • Serglycin
    • serglycin proteoglycan
    • Sgc
    • Srgn
    • SRGN_HUMAN
    see all
  • 功能Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 序列相似性Belongs to the serglycin family.
  • 翻译后修饰O-glcosylated; contains chondroitin sulfate and heparan sulfate.
  • 细胞定位Cytoplasmic granule. Secreted > extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.
  • Information by UniProt

Recombinant Human Serglycin protein 图像

  • 12.5% SDS-PAGE showing ab116977 at approximately 43.45kDa.
    Stained with Coomassie Blue.

Recombinant Human Serglycin protein (ab116977)参考文献

ab116977 has not yet been referenced specifically in any publications.

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