Recombinant人SCO2 protein (ab103492)

概述

  • 产品名称
    Recombinant人SCO2 protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMGPAETGGQGQPQGPGLRTRLLITGLFGAG LGGAWLALRAEKERLQQQKRTEALRQAAVGQGDFHLLDHRGRARCKADFR GQWVLMYFGFTHCPDICPDELEKLVQVVRQLEAEPGLPPVQPVFITVDPE RDDVEAMARYVQDFHPRLLGLTGSTKQVAQASHSYRVYYNAGPKDEDQDY IVDHSIAIYLLNPDGLFTDYYGRSRSAEQISDSVRRHMAAFRSVLS
    • 分子量
      27 kDa including tags
    • 氨基酸
      42 to 266
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab103492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab103492 was purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 30% Glycerol, 200mM Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • Cytochrome oxidase deficient homolog 2
    • MGC125823
    • MGC125825
    • OTTHUMP00000196774
    • OTTHUMP00000196775
    • Protein SCO2 homolog, mitochondrial
    • SCO (cytochrome oxidase deficient, yeast) homolog 2
    • SCO 1L
    • SCO 2
    • SCO cytochrome oxidase deficient homolog 2
    • SCO cytochrome oxidase deficient homolog 2 (yeast)
    • SCO1L
    • SCO2
    • SCO2_HUMAN
    • Synthesis of cytochrome c oxidase 2
    see all
  • 功能
    Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
  • 组织特异性
    Ubiquitous.
  • 疾病相关
    Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
  • 序列相似性
    Belongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3µg ab103492.

文献

ab103492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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