Recombinant人Sarcomeric Alpha Actinin protein (ab92234)

概述

  • 产品名称
    Recombinant人Sarcomeric Alpha Actinin protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      QAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPE KTM QAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRP AFMPSEGK MVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKF RQKASTHETWAYG KEQILLQKDYESASLTEVRALLRKHEAFESDLAAH QDRVEQIAAIAQELNELD YHDAVNVNDRCQKICDQWDRLGTLTQKRRE ALERMEKLLETIDQLHLEFAKRA APFNNWMEGAMEDLQDMFIVHSIEE IQSLITAHEQFKATLPEADGERQSIMAI QNEVEKVIQSYNIRISSSNP YSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR QHANERLRRQFAAQA NAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHN IINYKNNIDK LEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINE VETQI LTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLG EAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILAS DKP YILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSS
    • 氨基酸
      261 to 886

技术指标

Our Abpromise guarantee covers the use of ab92234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 复溶
    Reconstitution with 136 µl aqua dest.

常规信息

  • 别名
    • Actin binding protein
    • Actinin alpha 2
    • ACTN 2
    • ACTN2
    • ACTN2_HUMAN
    • Alpha actinin 2
    • Alpha actinin skeletal muscle
    • Alpha actinin skeletal muscle isoform 2
    • Alpha-actinin skeletal muscle isoform 2
    • Alpha-actinin-2
    • CMD1AA
    • F actin cross linking protein
    • F-actin cross-linking protein
    see all
  • 功能
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
  • 组织特异性
    Expressed in both skeletal and cardiac muscle.
  • 疾病相关
    Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性
    Belongs to the alpha-actinin family.
    Contains 1 actin-binding domain.
    Contains 2 CH (calponin-homology) domains.
    Contains 2 EF-hand domains.
    Contains 4 spectrin repeats.
  • 细胞定位
    Cytoplasm > myofibril > sarcomere > Z line. Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
  • Information by UniProt

图片

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

文献

ab92234 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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