Recombinant人RYK protein (ab114531)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP34925
    • 种属Human
    • 序列ELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVP SETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVF RVELSCTGKV
    • 分子量38 kDa including tags
    • 氨基酸54 to 163

技术指标

Our Abpromise guarantee covers the use of ab114531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • D3S3195
    • ERK 3
    • Hydroxyaryl protein kinase
    • JTK 5
    • JTK 5A
    • JTK5
    • JTK5A
    • JTK5A protein tyrosine kinase
    • receptor like tyrosine kinase
    • receptor like tyrosine kinase precursor
    • Ryk
    • RYK 1
    • RYK_HUMAN
    • RYK1
    • Tyrosine protein kinase RYK
    • Tyrosine protein kinase RYK precursor
    • Tyrosine-protein kinase RYK
    • Vik
    see all
  • 功能May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
  • 组织特异性Observed in all the tissues examined.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
    Contains 1 WIF domain.
  • 结构域The extracellular WIF domain is responsible for Wnt binding.
  • 翻译后修饰Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • 细胞定位Membrane. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
  • Information by UniProt

Recombinant Human RYK protein 图像

  • 12.5% SDS-PAGE showing ab114531 at approximately 37.73kDa stained with Coomassie Blue.

Recombinant Human RYK protein (ab114531)参考文献

ab114531 has not yet been referenced specifically in any publications.

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