Recombinant人ROR2 protein (ab70614)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      427 to 943

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技术指标

Our Abpromise guarantee covers the use of ab70614 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • BDB
    • BDB1
    • Brachydactyly type B
    • EC 2.7.10.1
    • MGC163394
    • Neurotrophic tyrosine kinase
    • Neurotrophic tyrosine kinase, receptor related 2
    • NTRKR2
    • Receptor tyrosine kinase-like orphan receptor 2
    • receptor-related 2
    • ROR2
    • ROR2_HUMAN
    • Tyrosine protein kinase transmembrane receptor ROR2
    • Tyrosine-protein kinase transmembrane receptor Ror2
    see all
  • 功能
    Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.
  • 疾病相关
    Brachydactyly B1
    Robinow syndrome autosomal recessive
  • 序列相似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    Contains 1 FZ (frizzled) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 kringle domain.
    Contains 1 protein kinase domain.
  • 发展阶段
    Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

图片

  • Kinase assay
  • SDS-PAGE showing ab70614 at approximately 86kDa.

文献

ab70614 has not yet been referenced specifically in any publications.

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