Recombinant人robld3 protein (ab101637)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9Y2Q5
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMGSHMLRPKALTQVLSQANTGGVQSTLLLN NEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDC MEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS
    • 分子量16 kDa including tags
    • 氨基酸1 to 125
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab101637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab101637 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • ENDAP
    • Endosomal adaptor protein p14
    • HSPC003
    • LAMTOR2
    • Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
    • Late endosomal/lysosomal Mp1 interacting protein
    • Late endosomal/lysosomal Mp1-interacting protein
    • LTOR2_HUMAN
    • MAPBPIP
    • MAPKSP1 adaptor protein
    • MAPKSP1AP
    • Mitogen activated protein binding protein interacting protein
    • Mitogen-activated protein-binding protein-interacting protein
    • p14
    • Ragulator complex protein LAMTOR2
    • Ragulator2
    • Roadblock domain containing 3
    • Roadblock domain containing protein 3
    • Roadblock domain-containing protein 3
    • ROBLD 3
    • RP11 336K24.9
    see all
  • 功能As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
  • 疾病相关Defects in LAMTOR2 are the cause of immunodeficiency due to defect in MAPBP-interacting protein (ID-MAPBPIP) [MIM:610798]. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency.
  • 序列相似性Belongs to the GAMAD family.
  • 细胞定位Late endosome membrane. Lysosome membrane.
  • Information by UniProt

Recombinant Human robld3 protein 图像

  • ab101637 (3 µg) analyzed by 15% SDS PAGE.

Recombinant Human robld3 protein (ab101637)参考文献

ab101637 has not yet been referenced specifically in any publications.

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