Recombinant人RING1 protein (ab112348)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ06587
    • 种属Human
    • 序列MDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRS GNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLS RLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEG EGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGS EDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYC QTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPGGGASDTGGP DGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSL TLELVNEKFWKVSRPLELCYAPTKDPK
    • 分子量67 kDa including tags
    • 氨基酸1 to 377
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

常规信息

  • 别名
    • Ring1A
    • E3 ubiquitin-protein ligase RING1
    • Polycomb complex protein RING1
    • Really interesting new gene 1 protein
    • RING finger protein 1
    • Ring1
    • RING1_HUMAN
    • RING1A
    • Rnf1
    • Transcription repressor Ring1A
    see all
  • 功能Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 RING-type zinc finger.
  • 细胞定位Nucleus speckle.
  • Information by UniProt

Recombinant Human RING1 protein 图像

  • 12.5% SDS-PAGE showing ab112348 at approximately 67.47kDa stained with Coomassie Blue.

Recombinant Human RING1 protein (ab112348)参考文献

ab112348 has not yet been referenced specifically in any publications.

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