Recombinant人Ribosomal protein S10 (ab116863)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP46783
    • 种属Human
    • 序列MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQ SLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPE TGKPRPKGLEGERPARLTRGEADRDTYRRSAVPPGADKKAEAGAGSATEF QFRGGFGRGRGQPPQ
    • 分子量44 kDa including tags
    • 氨基酸1 to 165

相关产品

技术指标

Our Abpromise guarantee covers the use of ab116863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 40S ribosomal protein S10
    • DBA9
    • MGC88819
    • OTTHUMP00000016229
    • OTTHUMP00000016230
    • RPS10
    • RS10_HUMAN
    • S10
    see all
  • 功能Component of the 40S ribosomal subunit.
  • 疾病相关Defects in RPS10 are the cause of Diamond-Blackfan anemia type 9 (DBA9) [MIM:613308]. It is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre- Robin syndrome and cleft palate), thumb and urogenital anomalies.
  • 序列相似性Belongs to the ribosomal protein S10e family.
  • 翻译后修饰Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.
  • 细胞定位Cytoplasm. Nucleus > nucleolus. Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Co-localizes with NPS1 in the GC region of the nucleolus.
  • Information by UniProt

Recombinant Human Ribosomal protein S10 图像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116863 at approximately 43.89 kDa.

Recombinant Human Ribosomal protein S10 (ab116863)参考文献

ab116863 has not yet been referenced specifically in any publications.

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