Recombinant人RGS4 protein (ab113136)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP49798
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMCKGLAGLPASCLRSAKDMKHRLGFLLQKS DSCEHNSSHNKKDKVVIC QRVSQEEVKKWAESLENLISHECGLAAFKA FLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQA TKE VNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLD LVNPSSCGAEKQKGAKSSADCA SLVPQCA
    • 分子量25 kDa including tags
    • 氨基酸1 to 205
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab113136 was purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.08% DTT, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • MGC2124
    • MGC60244
    • Regulator of G protein signalling 4
    • Regulator of G-protein signaling 4
    • RGP 4
    • RGP4
    • RGS 4
    • RGS4
    • RGS4_HUMAN
    • Schizophrenia disorder 9
    • SCZD 9
    • SCZD9
    see all
  • 功能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • 疾病相关Genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 序列相似性Contains 1 RGS domain.
  • 翻译后修饰Palmitoylated on Cys-2 and/or Cys-12.
    Phosphorylated by cyclic GMP-dependent protein kinase.
  • Information by UniProt

Recombinant Human RGS4 protein 图像

  • 15% SDS-PAGE analysis of 3 µg ab113136.

Recombinant Human RGS4 protein (ab113136)参考文献

ab113136 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab113136.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"