Recombinant人RGS2 protein (ab104636)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP41220
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMQSAMFLAVQHDCRPMDKSAGSGHKSEEKR EKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLW SEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSS KARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSL MENNSYPRFLESEFYQDLCKKPQITTEPHAT
    • 分子量27 kDa including tags
    • 氨基酸1 to 211
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab104636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab104636 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0

常规信息

  • 别名
    • Basic helix-loop-helix phosphoprotein G0S8
    • Cell growth inhibiting protein 31
    • Cell growth-inhibiting gene 31 protein
    • G0 to G1 switch regulatory 8 24kD
    • G0/G1 switch regulatory protein 8
    • G0S8
    • GOS8
    • OTTHUMP00000060765
    • Regulator of G protein signaling 2
    • Regulator of G protein signalling 2 24kD
    • Regulator of G-protein signaling 2
    • Regulators of G protein signaling XRGSVI
    • RGS 2
    • RGS2
    • RGS2_HUMAN
    see all
  • 功能Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).
  • 组织特异性Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
  • 序列相似性Contains 1 RGS domain.
  • 翻译后修饰Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
  • 细胞定位Cell membrane. Mitochondrion and Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • Information by UniProt

Recombinant Human RGS2 protein 图像

  • 15% SDS-PAGE analysis of 3µg ab104636.

Recombinant Human RGS2 protein (ab104636)参考文献

ab104636 has not yet been referenced specifically in any publications.

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