Retinally abundant regulator of G protein signaling
Retinally abundant regulator of G-protein signaling
功能Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.
组织特异性Abundantly expressed in retina with lower levels of expression in most other tissues.
序列相似性Contains 1 RGS domain.
翻译后修饰Palmitoylated on Cys-2 and/or Cys-12. Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.