Recombinant人Reg3a protein (ab73486)
- 数据表
- 具体的参考文献 (1)
- 实验方案
概述
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产品名称Recombinant人Reg3a protein
参阅全部 Reg3a 蛋白酶 -
蛋白长度Full length protein
描述
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性质Recombinant
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来源Escherichia coli
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氨基酸序列
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种属Human
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序列MRGSHHHHHH GMASHMEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD
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分子量18 kDa
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氨基酸27 to 175
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额外的序列信息The Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab73486 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Western blot
ELISA
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纯度> 95 % SDS-PAGE.
ab73486 is purified by a one-step procedure using affinity Ni-NTA chromatography. -
形式Lyophilised
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: None
Constituents: 0.05M Acetate buffer, pH4
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复溶Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10µg/ml. In higher concentrations the solubility of this antigen is limited.
常规信息
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别名
- FLJ18565
- Hepatocarcinoma intestine pancreas
- Hepatointestinal pancreatic protein
see all -
功能Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
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组织特异性Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
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序列相似性Contains 1 C-type lectin domain.
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结构域The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
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翻译后修饰Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
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细胞定位Secreted. Found in the apical region of pancreatic acinar cells.
- Information by UniProt
Recombinant Human Reg3a protein (ab73486)参考文献
This product has been referenced in:
- Cui W et al. Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells. Growth Factors 27:195-202 (2009). WB . Read more (PubMed: 19343564) »
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"