-
别名
- FLJ18565
- Hepatocarcinoma intestine pancreas
- Hepatointestinal pancreatic protein
- HIP
- HIP/PAP
- Human proislet peptide
- INGAP
- Pancreatic beta cell growth factor
- Pancreatitis associated protein
- Pancreatitis associated protein 1
- Pancreatitis-associated protein 1
- PAP
- PAP H
- PAP homologous protein
- PAP1
- PBCGF
- Proliferation inducing protein 34
- Proliferation inducing protein 42
- REG III
- Reg III alpha
- Reg III-alpha
- REG-3-alpha
- REG3
- Reg3a
- REG3A_HUMAN
- Regenerating islet derived 3 alpha
- Regenerating islet derived protein 3 alpha precursor
- Regenerating islet-derived protein 3-alpha 15 kDa form
- Regenerating islet-derived protein III-alpha
see all
-
功能
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
-
组织特异性
Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
-
序列相似性
Contains 1 C-type lectin domain.
-
结构域
The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
-
翻译后修饰
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
-
细胞定位
Secreted. Found in the apical region of pancreatic acinar cells.
-
Information by UniProt