Recombinant人RASA1 protein (ab116965)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP20936
    • 种属Human
    • 序列AKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAA LHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
    • 分子量37 kDa including tags
    • 氨基酸948 to 1047

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技术指标

Our Abpromise guarantee covers the use of ab116965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CM AVM
    • CMAVM
    • DKFZp434N071
    • GAP
    • GTPase activating protein
    • GTPase-activating protein
    • OTTHUMP00000222390
    • OTTHUMP00000222391
    • OTTHUMP00000222392
    • OTTHUMP00000222393
    • p120GAP
    • p120RASGAP
    • PKWS
    • Ras GTPase-activating protein 1
    • Ras p21 protein activator
    • RAS p21 protein activator (GTPase activating protein) 1
    • RASA
    • RASA1
    • RASA1_HUMAN
    • RasGAP
    • Triphosphatase activating protein
    see all
  • 功能Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
  • 组织特异性In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
  • 疾病相关Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
    Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
    Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
  • 序列相似性Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human RASA1 protein 图像

  • 12.5% SDS-PAGE showing ab116965 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human RASA1 protein (ab116965)参考文献

ab116965 has not yet been referenced specifically in any publications.

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