功能Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
组织特异性Expressed in red blood cells (at protein level).
序列相似性Belongs to the small GTPase superfamily. Ras family.
结构域The effector domain mediates the interaction with RUNDC3A.
翻译后修饰Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
细胞定位Recycling endosome membrane. Associated with red blood cells-released vesicles.