Recombinant人Ran (mutated E70 A) protein (ab90203)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 修饰mutated E70A

技术指标

Our Abpromise guarantee covers the use of ab90203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Protein preparation is 85% GDP-loaded, measured by HPLC.
  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明


    The mutation E70A results in inhibition of the guanine exchange reaction mediated by RCC1, the guanine nucleotide exchange factor (GEF) for Ran.

    Protein preparation is 85% GDP-loaded, measured by HPLC.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 5mM Magnesium chloride, 20mM Potassium phosphate, 1mM DTE (1, 4-Dithioerythritol), pH 7.4

常规信息

  • 别名
    • Androgen receptor associated protein 24
    • Androgen receptor-associated protein 24
    • ARA 24
    • ARA24
    • Gsp1
    • GTP binding nuclear protein RAN
    • GTP-binding nuclear protein Ran
    • GTPase Ran
    • Guanosine triphosphatase Ran
    • LPS
    • OK/SW-cl.81
    • ran
    • RAN member RAS oncogene family
    • RAN_HUMAN
    • RanGTPase
    • Ras like protein TC4
    • Ras related nuclear protein
    • Ras-like protein TC4
    • Ras-related nuclear protein
    • RASL2 8
    • TC 4
    • TC4
    see all
  • 功能GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • 组织特异性Expressed in a variety of tissues.
  • 序列相似性Belongs to the small GTPase superfamily. Ran family.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Recombinant Human Ran (mutated E70 A) protein (ab90203)参考文献

ab90203 has not yet been referenced specifically in any publications.

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