Recombinant人Rad51C protein (ab114641)

概述

  • 产品名称
    Recombinant人Rad51C protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEV GISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFI ITFCSALDDILGGGVPLMKTTEICGAPGVGKTQL
    • 分子量
      40 kDa including tags
    • 氨基酸
      1 to 134

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • BROVCA3
    • DNA repair protein RAD51 homolog 3
    • FANCO
    • MGC104277
    • R51H3
    • RA51C_HUMAN
    • Rad 51C
    • RAD51 homolog C
    • RAD51 homolog C (S. cerevisiae)
    • Rad51 homolog c (S. cerevisiae), isoform CRA_b
    • RAD51 like protein 2
    • RAD51 paralog C
    • RAD51, S. cerevisiae, homolog of, C
    • RAD51-like protein 2
    • RAD51C
    • RAD51C protein
    • RAD51L2
    • RAD51L2/RAD51C protein
    • RGD1563765
    • Yeast RAD51 homolog 3
    see all
  • 功能
    Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.
  • 组织特异性
    Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
  • 疾病相关
    Defects in RAD51C are the cause of Fanconi anemia complementation group O (FANCO) [MIM:613390]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in RAD51C are the cause of breast-ovarian cancer familial type 3 (BROVCA3) [MIM:613399]. It is a condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
  • 序列相似性
    Belongs to the RecA family. RAD51 subfamily.
  • 细胞定位
    Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion. DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE image showing ab114641 Stained with Coomassie Blue.

文献

ab114641 has not yet been referenced specifically in any publications.

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