Recombinant人Rad1 protein (ab123485)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO60671
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MPLLTQQIQD EDDQYSLVAS LDNVRNLSTI LKAIHFREHA TCFATKNGIK VTVENAKCVQ ANAFIQAGIF QEFKVQEESV TFRINLTVLL DCLSIFGSSP MPGTLTALRM CYQGYGYPLM LFLEEGGVVT VCKINTQEPE ETLDFDFCST NVINKIILQS EGLREAFSEL DMTSEVLQIT MSPDKPYFRL STFGNAGSSH LDYPKDSDLM EAFHCNQTQV NRYKISLLKP STKALVLSCK VSIRTDNRGF LSLQYMIRNE DGQICFVEYY CCPDEEVPES ES
    • 分子量34 kDa including tags
    • 氨基酸1 to 282
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123485 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab123485 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式Liquid
  • 补充说明Please prevent freeze thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.02% DTT, 0.24% Tris, 10% Glycerol, 1.17% Sodium chloride

常规信息

  • 别名
    • Cell cycle checkpoint protein Hrad1
    • Cell cycle checkpoint protein Rad 1 A / B
    • Cell cycle checkpoint protein RAD1
    • Checkpoint control protein HRAD1
    • Checkpoint control protein RAD1
    • DNA repair exonuclease
    • DNA repair exonuclease rad1
    • DNA repair exonuclease rad1 homolog
    • DNA repair exonuclease REC1
    • DNA repair protein RAD1
    • EC 3.1.11.2
    • Exonuclease homolog RAD1
    • GTP-binding protein RAD
    • hRAD 1
    • hRAD1
    • MGC77779
    • RAD
    • RAD 1
    • RAD1
    • RAD1 homolog
    • RAD1 homolog (S. pombe)
    • Rad1 like DNA damage checkpoint
    • Rad1 like DNA damage checkpoint protein
    • RAD1, S. pombe, homolog of
    • Rad1-like DNA damage checkpoint protein
    • RAD1_HUMAN
    • Ras associated with diabetes
    • REC 1
    • REC1
    • RRAD
    see all
  • 功能Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
  • 组织特异性Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
  • 序列相似性Belongs to the rad1 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human Rad1 protein (ab123485)参考文献

ab123485 has not yet been referenced specifically in any publications.

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