概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      EHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANIN VENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCVLL
    • 分子量
      37 kDa including tags
    • 氨基酸
      108 to 207

技术指标

Our Abpromise guarantee covers the use of ab152526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AA409338
    • MEL
    • Mel transforming oncogene
    • Mel transforming oncogene (derived from cell line NK14)
    • Mel transforming oncogene (derived from cell line NK14) RAB8 homolog
    • Mel transforming oncogene (RAB8 homolog)
    • MGC124948
    • Oncogene c mel
    • Oncogene c-mel
    • RAB8
    • RAB8A
    • RAB8A member RAS oncogene family
    • RAB8A_HUMAN
    • Ras associated protein RAB8
    • Ras related protein Rab 8A
    • Ras-related protein Rab-8A
    see all
  • 功能
    May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.
  • 序列相似性
    Belongs to the small GTPase superfamily. Rab family.
  • 细胞定位
    Cell membrane. Golgi apparatus. Cytoplasm > perinuclear region. Cell projection. Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152526 stained with Coomassie Blue.

文献

ab152526 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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