Recombinant人PTS protein (ab116410)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE.
    • 分子量
      19 kDa including tags
    • 氨基酸
      1 to 145
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab116410 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式
    Liquid
  • 补充说明
    Although stable at 4°C for 4 weeks, ab116410 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 20% Glycerol, 0.32% Tris HCl, 0.02% DTT

常规信息

  • 别名
    • 6 pyruvoyl tetrahydrobiopterin synthase
    • 6 pyruvoyl tetrahydropterin synthase
    • 6 pyruvoyltetrahydropterin synthase
    • 6-pyruvoyl tetrahydrobiopterin synthase
    • EC 4.2.3.12
    • FLJ97081
    • OTTHUMP00000235385
    • PTP synthase
    • PTPS
    • PTPS_HUMAN
    • PTS
    see all
  • 功能
    Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • 通路
    Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • 疾病相关
    Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • 序列相似性
    Belongs to the PTPS family.
  • 翻译后修饰
    Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt

文献

ab116410 has not yet been referenced specifically in any publications.

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