Recombinant人PTPRB protein (ab42583)

概述

  • 产品名称
    Recombinant人PTPRB protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      1675 to 1996

技术指标

Our Abpromise guarantee covers the use of ab42583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Specific Activity: 40 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP.
  • 应用

    Inhibition Assay

    Functional Studies

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • HPTP BETA
    • HPTPB
    • Phosphacan receptor type B
    • Protein tyrosine phosphatase receptor type B
    • Protein-tyrosine phosphatase beta
    • PTPB
    • Ptprb
    • PTPRB_HUMAN
    • R PTP BETA
    • R-PTP-beta
    • Receptor-type tyrosine-protein phosphatase beta
    • RPTPB
    • Vascular endothelial protein tyrosine phosphatase
    • VE-PTP
    see all
  • 功能
    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin.
  • 序列相似性
    Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 17 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 细胞定位
    Membrane.
  • Information by UniProt

文献

ab42583 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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