Recombinant人PTPD2 protein (ab42582)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸817 to 1188

技术指标

Our Abpromise guarantee covers the use of ab42582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 20 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM Pnpp, and 5µg/ml enzyme.
  • 应用

    Functional Studies

    Inhibition Assay

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Cytoskeletal associated protein tyrosine phosphatase
    • MGC126803
    • PEZ
    • Phosphatase with ezrin domain
    • Protein tyrosine phosphatase non receptor type 14
    • Protein tyrosine phosphatase pez
    • Protein-tyrosine phosphatase pez
    • PTN14_HUMAN
    • PTP 36
    • PTP36
    • PTPD 2
    • PTPN 14
    • PTPN14
    • Tyrosine protein phosphatase non receptor type 14
    • Tyrosine-protein phosphatase non-receptor type 14
    see all
  • 功能Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.
  • 组织特异性Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.
  • 疾病相关Defects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    Contains 1 FERM domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm > cytoskeleton.
  • Information by UniProt

Recombinant human PTPD2 protein (ab42582)参考文献

ab42582 has not yet been referenced specifically in any publications.

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