The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性Specific Activity: 20 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM Pnpp, and 5µg/ml enzyme.
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Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cytoskeletal associated protein tyrosine phosphatase
Phosphatase with ezrin domain
Protein tyrosine phosphatase non receptor type 14
Protein tyrosine phosphatase pez
Protein-tyrosine phosphatase pez
Tyrosine protein phosphatase non receptor type 14
Tyrosine-protein phosphatase non-receptor type 14
功能Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.
组织特异性Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.
疾病相关Defects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 tyrosine-protein phosphatase domain.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.