Recombinant人PTP4A3 protein (ab87716)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

技术指标

Our Abpromise guarantee covers the use of ab87716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 95 % SDS-PAGE.
    ab87716 is purified using conventional chromatography techniques. Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method).
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Potentially prenylated protein tyrosine phosphatase
    • PRL 3
    • PRL R
    • PRL-3
    • PRL-R
    • PRL3
    • PRLR
    • Protein tyrosine phosphatase 4a3
    • Protein tyrosine phosphatase type IVA 3
    • Protein-tyrosine phosphatase 4a3
    • Protein-tyrosine phosphatase of regenerating liver 3
    • PTP 4A3
    • PTP4A3
    • TP4A3_HUMAN
    see all
  • 功能Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
  • 组织特异性Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Farnesylated. Farnesylation is required for membrane targeting.
  • 细胞定位Cell membrane. Early endosome.
  • Information by UniProt

Recombinant Human PTP4A3 protein 图像

  • 15% SDS-PAGE showing ab87716 at approximately 21.6kDa (3µg).
  • All lanes : Anti-PTP4A3 antibody (ab82568) at 1 µg/ml

    Lane 1 : Recombinant Human PTP4A3 protein (ab87716) at 0.01 µg
    Lane 2 : Recombinant Human PTP4A3 protein (ab87716) at 0.1 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 20 seconds

Recombinant Human PTP4A3 protein (ab87716)参考文献

ab87716 has not yet been referenced specifically in any publications.

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