Recombinant人PTP4A1 protein (ab42567)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 氨基酸
      2 to 173

技术指标

Our Abpromise guarantee covers the use of ab42567 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    0.45 U/ug. One unit will hydrolyze 1 pmol 6, 8-difluoro-4-methyl umbelliferyl phosphate (DiFMUP) per minute at pH 6.3 and 30?C. Assay buffer: 50 mM Bis-Tris, pH 6.3, 2 mM EDTA, 2 mM DTT, 100 mM DiFMUP.
  • 应用

    Inhibition Assay

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Liquid
  • 补充说明
    0.45 U/ug. One unit will hydrolyze 1 pmol 6, 8-difluoro-4-methyl umbelliferyl phosphate (DiFMUP) per minute at pH 6.3 and 30?C. Assay buffer: 50 mM Bis-Tris, pH 6.3, 2 mM EDTA, 2 mM DTT, 100 mM DiFMUP.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8

常规信息

  • 别名
    • HH 72
    • HH72
    • Hypothetical protein DKFZp779M0721
    • Phosphatase of regenerating liver 1
    • PRL 1
    • PRL-1
    • PRL1
    • Protein tyrosine phosphatase PTPCAAX1
    • Protein tyrosine phosphatase type IVA 1
    • Protein tyrosine phosphatase type IVA member 1
    • Protein-tyrosine phosphatase 4a1
    • Protein-tyrosine phosphatase of regenerating liver 1
    • Protein-tyrosine phosphatase, type 4A, 1
    • PTP(CAAXI)
    • Ptp4a1
    • PTPCAAX1
    • TP4A1_HUMAN
    see all
  • 功能
    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
  • 组织特异性
    Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
  • 序列相似性
    Belongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • 发展阶段
    Expressed in fetal liver.
  • 翻译后修饰
    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • 细胞定位
    Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm > cytoskeleton > spindle. And mitotic spindle.
  • Information by UniProt

Recombinant Human PTP4A1 protein (ab42567)参考文献

ab42567 has not yet been referenced specifically in any publications.

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