Protein-tyrosine phosphatase of regenerating liver 1
Protein-tyrosine phosphatase, type 4A, 1
功能Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
组织特异性Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
序列相似性Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.
发展阶段Expressed in fetal liver.
翻译后修饰Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
细胞定位Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm > cytoskeleton > spindle. And mitotic spindle.