Recombinant人PTHLH protein (ab51706)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab51706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    >98% by SDS-PAGE and HPLC analysis. Endotoxin level is <0.1 ng per µg of PTHrP. Sterile filtered.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, pH 7.1

  • 复溶
    Reconstitute in water to a concentration of 1.0 mg/ml.

常规信息

  • 别名
    • HHM
    • MGC14611
    • Osteostatin
    • Parathyroid hormon like hormone isoform 2 preproprotein
    • Parathyroid hormone like hormone
    • Parathyroid hormone like hormone isoform 1 preproprotein
    • Parathyroid hormone like protein
    • Parathyroid hormone like related protein
    • Parathyroid hormone related protein
    • Parathyroid hormone-like protein
    • Parathyroid like protein
    • PLP
    • PTH related protein
    • PTH-rP
    • PTHLH
    • PTHR
    • PTHR_HUMAN
    • PTHrP
    • PTHrP[107-139]
    see all
  • 功能
    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.
  • 组织特异性
    Ubiquitous. Also expressed in the mammary gland.
  • 疾病相关
    Brachydactyly E2
  • 序列相似性
    Belongs to the parathyroid hormone family.
  • 翻译后修饰
    There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
  • 细胞定位
    Cytoplasm. Nucleus. Secreted.
  • Information by UniProt

文献

ab51706 has not yet been referenced specifically in any publications.

客户评价及客户问答

Thank you for your enquiry. The only additional information that I was able to find is that this recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues. I hope this information helps, please do not hesitate to contact us i...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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