Proteasome (prosome macropain) subunit beta type 10
Proteasome beta 10 subunit
Proteasome catalytic subunit 2i
Proteasome MECl 1
Proteasome subunit beta 2i
Proteasome subunit beta 7i
Proteasome subunit beta type 10
Proteasome subunit beta type-10
Proteasome subunit beta-2i
Proteasome subunit MECL1
功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
序列相似性Belongs to the peptidase T1B family.
发展阶段Highly expressed in immature dendritic cells (at protein level).
翻译后修饰Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.