Recombinant人PSMA protein (ab117471)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ04609
    • 种属Human
    • 序列MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP NKTHPNYISI INEDGNEIFN TSLFEPPPPG
    • 分子量43 kDa including tags
    • 氨基酸1 to 150
    • 额外的序列信息PSMA Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 150 amino acids (1-150 a.a.) fused to a GST tag and having a total molecular mass of 43kDa.

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技术指标

Our Abpromise guarantee covers the use of ab117471 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • Cell growth inhibiting protein 27
    • Cell growth-inhibiting gene 27 protein
    • FGCP
    • Folate hydrolase
    • Folate hydrolase (prostate-specific membrane antigen) 1
    • Folate hydrolase 1
    • Folate hydrolase prostate specific membrane antigen 1
    • FOLH
    • FOLH 1
    • Folh1
    • FOLH1_HUMAN
    • Folylpoly gamma glutamate carboxypeptidase
    • Folylpoly-gamma-glutamate carboxypeptidase
    • GCP 2
    • GCP II
    • GCP2
    • GCPII
    • GIG27
    • Glutamate carboxylase II
    • Glutamate carboxypeptidase 2
    • Glutamate carboxypeptidase II
    • Membrane glutamate carboxypeptidase
    • mGCP
    • N acetylated alpha linked acidic dipeptidase 1
    • N-acetylated-alpha-linked acidic dipeptidase I
    • NAALAD 1
    • NAALAD1
    • NAALAdase
    • NAALADase I
    • Prostate specific membrane antigen
    • Prostate specific membrane antigen variant F
    • Prostate-specific membrane antigen
    • PSM
    • PSMA
    • Pteroylpoly gamma glutamate carboxypeptidase
    • Pteroylpoly-gamma-glutamate carboxypeptidase
    see all
  • 功能Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
    Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
  • 组织特异性Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
  • 序列相似性Belongs to the peptidase M28 family. M28B subfamily.
  • 结构域The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
  • 翻译后修饰The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
    The N-terminus is blocked.
  • 细胞定位Cytoplasm and Cell membrane.
  • Information by UniProt

Recombinant Human PSMA protein (ab117471)参考文献

ab117471 has not yet been referenced specifically in any publications.

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