Recombinant人PSIP1 protein (ab82129)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸322 to 530

技术指标

Our Abpromise guarantee covers the use of ab82129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

常规信息

  • 别名
    • CLL associated antigen KW 7
    • CLL-associated antigen KW-7
    • Dense fine speckles 70 kDa protein
    • DFS 70
    • DFS70
    • LEDGF
    • Lens epithelium derived growth factor
    • Lens epithelium-derived growth factor
    • MGC74712
    • p52
    • p75
    • PAIP
    • PC4 and SFRS1 interacting protein
    • PC4 and SFRS1 interacting protein 1
    • PC4 and SFRS1 interacting protein 2
    • PC4 and SFRS1-interacting protein
    • PSIP 1
    • PSIP 2
    • Psip1
    • PSIP1_HUMAN
    • PSIP2
    • Transcriptional coactivator p75/p52
    see all
  • 功能Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
  • 组织特异性Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
  • 疾病相关Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
  • 序列相似性Belongs to the HDGF family.
    Contains 1 PWWP domain.
  • 结构域Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Remains chromatin-associated throughout the cell cycle.
  • Information by UniProt

Recombinant Human PSIP1 protein (ab82129)参考文献

ab82129 has not yet been referenced specifically in any publications.

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