Recombinant人PSD95 protein (ab114158)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP78352
    • 种属Human
    • 序列QGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQAR KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPAR ER
    • 分子量37 kDa including tags
    • 氨基酸665 to 766

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技术指标

Our Abpromise guarantee covers the use of ab114158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    ab is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Discs large homolog 4
    • Disks large homolog 4
    • DLG 4
    • Dlg4
    • DLG4_HUMAN
    • FLJ97752
    • FLJ98574
    • Human post synaptic density protein 95
    • Post synaptic density protein 95
    • Postsynaptic density protein 95
    • PSD 95
    • PSD-95
    • PSD95
    • SAP 90
    • SAP-90
    • SAP90
    • Synapse associated protein 90
    • Synapse-associated protein 90
    • Tax interaction protein 15
    see all
  • 功能Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
  • 组织特异性Brain.
  • 序列相似性Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
  • 结构域The PDZ domain 3 mediates interaction with ADR1B.
    The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density.
  • 翻译后修饰Palmitoylation of isoform 1 is required for targeting to postsynaptic density.
  • 细胞定位Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
  • Information by UniProt

Recombinant Human PSD95 protein 图像

  • 12.5% SDS-PAGE analysis of ab114158, stained with Coomassie Blue.

Recombinant Human PSD95 protein (ab114158)参考文献

ab114158 has not yet been referenced specifically in any publications.

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