Recombinant人PROX1 protein (ab54337)

概述

  • 产品名称
    Recombinant人PROX1 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYT RYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIND GVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNA IIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
    • 分子量
      22 kDa
    • 氨基酸
      547 to 737

技术指标

Our Abpromise guarantee covers the use of ab54337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    >95% by SDS-PHAGE & silver stain.
  • 形式
    Lyophilised
  • 补充说明

    This product can be used as a positive control e.g. in Western analysis.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • 复溶
    Reconstitute in water to a concentration not lower than 50 µg/ml.

常规信息

  • 别名
    • Homeobox prospero like protein
    • Homeobox prospero like protein PROX1
    • Homeobox prospero-like protein PROX1
    • Prospero homeobox 1
    • Prospero homeobox protein 1
    • Prospero related homeobox 1
    • prospero-related homeobox gene 1
    • PROX 1
    • PROX-1
    • PROX1
    • PROX1_HUMAN
    • zgc:111888
    see all
  • 功能
    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 组织特异性
    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 序列相似性
    Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • 结构域
    The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • 细胞定位
    Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt

图片

  • SDS-PAGE analysis of recombinant human PROX1 protein fragment (ab54337). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.

文献

ab54337 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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