Recombinant人Protein Phosphatase 1 beta (ab126018)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP62140
    • 种属Human
    • 氨基酸30 to 319

技术指标

Our Abpromise guarantee covers the use of ab126018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • MGC3672
    • PP 1B
    • PP-1B
    • PP1B
    • PP1B_HUMAN
    • PP1beta
    • PPP1CB
    • PPP1CD
    • Protein phosphatase 1 beta
    • Protein phosphatase 1 catalytic subunit beta isoform
    • Protein phosphatase 1 delta
    • Protein phosphatase 1, catalytic subunit, beta isozyme
    • Protein phosphatase 1, catalytic subunit, delta isoform
    • Serine threonine protein phosphatase PP1 beta catalytic subunit
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    see all
  • 功能Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 细胞定位Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt

Recombinant Human Protein Phosphatase 1 beta (ab126018)参考文献

ab126018 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab126018.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"