Recombinant人Proteasome 26S S10 protein (ab78763)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG

相关产品

技术指标

Our Abpromise guarantee covers the use of ab78763 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab78763 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, PBS, pH 7.4

常规信息

  • 别名
    • 26S proteasome non-ATPase regulatory subunit 10
    • 26S proteasome regulatory subunit p28
    • Ankyrin repeat protein
    • dJ889N15.2
    • Gankyrin
    • Hepatocellular carcinoma-associated protein p28 II
    • p28
    • p28(GANK)
    • Proteasome (prosome, macropain) 26S subunit, non ATPase, 10
    • PSD10_HUMAN
    • Psmd10
    see all
  • 功能Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module.
    Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
  • 组织特异性Overexpressed in hepatocellular carcinomas.
  • 序列相似性Contains 7 ANK repeats.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human Proteasome 26S S10 protein 图像

  • 15% SDS-PAGE showing ab78763 at approximately 24kDa (3µg).

Recombinant Human Proteasome 26S S10 protein (ab78763)参考文献

ab78763 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab78763.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"