Recombinant人Prostaglandin D Synthase (hematopoietic) protein (ab88041)

概述

描述

  • 性质
    Recombinant
  • 来源
    Saccharomyces cerevisiae
  • 氨基酸序列
    • 种属
      Human
    • 序列
      MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGK IPILE VDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDF MSCFPWAEKKQD VKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSV TWADFYWEICSTTLLVFKP DLLDNHPRLVTLRKKVQAIPAVANWIKRR PQTKL

技术指标

Our Abpromise guarantee covers the use of ab88041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

常规信息

  • 别名
    • Cerebrin 28
    • Glutathione dependent PGD synthetase
    • Glutathione S-transferase
    • Glutathione-dependent PGD synthase
    • Glutathione-requiring prostaglandin D synthase
    • GST class-sigma
    • H PGDS
    • H-PGDS
    • Haematopoietic prostaglandin D synthase
    • Haematopoietic prostaglandin D2 synthase
    • Hematopoietic prostaglandin D synthase
    • Hpgds
    • HPGDS_HUMAN
    • Prostaglandin D synthase
    • Prostaglandin D2 synthase hematopoietic
    • Prostaglandin H2 D isomerase
    • Prostaglandin-H2 D-isomerase
    • PTGDS2
    see all
  • 功能
    Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
  • 组织特异性
    Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.
  • 序列相似性
    Belongs to the GST superfamily. Sigma family.
    Contains 1 GST C-terminal domain.
    Contains 1 GST N-terminal domain.
  • 发展阶段
    Highest levels in immature megakaryocytic cells. Disappears after final differentiation to platelets.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

文献

ab88041 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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