Recombinant人Prokineticin 1 protein (ab69789)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Ile-Thr-Gly.
    • 分子量
      10 kDa
    • 额外的序列信息
      EG-VEGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids and having a molecular mass of 9605 Dalton.

相关产品

技术指标

Our Abpromise guarantee covers the use of ab69789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. Sterile Filtered. Purified by proprietary chromatographic techniques.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    No additives

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    Reconstitute in sterile 18MOhm/cm water to not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

常规信息

  • 别名
    • Black mamba toxin related protein
    • EG VEGF
    • EG-VEGF
    • EGVEGF
    • Endocrine-gland-derived vascular endothelial growth factor
    • Mambakine
    • PK1
    • PRK1
    • PROK1
    • PROK1_HUMAN
    • Prokineticin-1
    see all
  • 功能
    Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
  • 组织特异性
    Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
  • 序列相似性
    Belongs to the AVIT (prokineticin) family.
  • 发展阶段
    In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.
  • 细胞定位
    Secreted.
  • Information by UniProt

Recombinant human Prokineticin 1 protein (ab69789)参考文献

ab69789 has not yet been referenced specifically in any publications.

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