Recombinant人Progerin protein (ab93918)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸1 to 614

相关产品

技术指标

Our Abpromise guarantee covers the use of ab93918 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Constituents: 20% Glycerol, 0.315% Tris HCl, 2.922% Sodium chloride, 0.015% DTT, 0.044% EDTA

常规信息

  • 别名
    • 70 kDa lamin
    • CDCD1
    • CDDC
    • CMD1A
    • CMT2B1
    • EMD2
    • FPL
    • FPLD
    • HGPS
    • IDC
    • LA delta 50
    • Lamin A delta 50
    • LDP1
    • LFP
    • LGMD1B
    • LMN1
    • LMNA
    • LMNC
    • PRO1
    • renal carcinoma antigen NYREN32
    see all
  • 相关性Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin A and C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acids internal deletion within the carboxyl-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of LMNA gene.
  • 细胞定位Cell Membrane, Cytoplasmic, intermediate filament and Nuclear

Recombinant Human Progerin protein (ab93918)参考文献

ab93918 has not yet been referenced specifically in any publications.

Product Wall


ab93918 is a 614 amino acid protein of molecular weight 68 kDa. The accession number is AAR29466.1 (see link below):

http://www.ncbi.nlm.nih.gov/protein/AAR29466

We have not done any testing to indicate whether or not the protein...

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Thank you for your inquiry. We do have a human progerin protein in the catalogue as ab93918 that can be used as a positive control in WB. http://www.abcam.com/Progerin-protein-Human-ab93918.html I hope this information helps.  Please contac...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"