Recombinant人PPP2R5C protein (ab114678)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCC VLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFA
    • 分子量
      37 kDa including tags
    • 氨基酸
      1 to 100

技术指标

Our Abpromise guarantee covers the use of ab114678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 2A5G_HUMAN
    • B' alpha regulatory subunit
    • B56G
    • KIAA0044
    • MGC23064
    • PP2A B subunit B' gamma isoform
    • PP2A B subunit B56 gamma isoform
    • PP2A B subunit isoform B' gamma
    • PP2A B subunit isoform B''-gamma
    • PP2A B subunit isoform B56-gamma
    • PP2A B subunit isoform PR61-gamma
    • PP2A B subunit isoform R5-gamma
    • PP2A B subunit PR61 gamma isoform
    • PP2A B subunit R5 gamma isoform
    • Ppp2r5c
    • PR61G
    • Protein phosphatase 2 regulatory subunit B (B56) gamma isoform
    • Protein phosphatase 2 regulatory subunit B' gamma
    • Protein phosphatase 2, regulatory subunit B', gamma isoform
    • Renal carcinoma antigen NY REN 29
    • Renal carcinoma antigen NY-REN-29
    • Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    see all
  • 功能
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
  • 组织特异性
    Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
  • 序列相似性
    Belongs to the phosphatase 2A regulatory subunit B56 family.
  • 翻译后修饰
    Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • 细胞定位
    Nucleus. Chromosome > centromere.
  • Information by UniProt

图片

  • ab114678 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

文献

ab114678 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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