Recombinant人POT1 protein (ab112404)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIV DQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQG
    • 分子量
      36 kDa including tags
    • 氨基酸
      1 to 95

技术指标

Our Abpromise guarantee covers the use of ab112404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式
    Liquid
  • 补充说明
    Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • DKFZP586D211
    • hPot 1
    • hPot1
    • POT 1
    • POT1
    • POT1 like telomere end-binding protein
    • POT1 protection of telomeres 1 homolog
    • POT1-like telomere end-binding protein
    • POTE1_HUMAN
    • Protection of telomeres 1
    • Protection of telomeres 1 homolog (S. pombe)
    • Protection of telomeres protein 1
    see all
  • 功能
    Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the telombin family.
  • 细胞定位
    Nucleus. Chromosome > telomere. Colocalizes with telomeric DNA.
  • Information by UniProt

Recombinant Human POT1 protein 图像

  • 12.5% SDS-PAGE analysis of ab112404. Stained with Coomassie Blue

Recombinant Human POT1 protein (ab112404)参考文献

ab112404 has not yet been referenced specifically in any publications.

Product Wall

Thanks for your inquiry. ab112404 binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats(G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. It binds telomeric single-stranded sequenc...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册